Improving the Powder Properties of an Active Pharmaceutical Ingredient (Ethenzamide) with a Silica Nanoparticle Coating for Direct Compaction into Tablets

To improve the powder properties of active pharmaceutical ingredients (APIs), we coated APIs with silica nanoparticles using a dry process that allowed for direct compression into tablets. The coating performed different apparatuses (a batch-type high-speed shear mixer (Mechanomill) and continuous conical screen mill (Comil)) resulting dry-coated were compared. Ethenzamide (ETZ), which has low flowability, was selected as host particle to be improved colloidal silicas Aerosil 200 R972 used guest particles. Both processes types flowability (angle repose) ETZ under unstressed conditions. Inverse gas chromatography demonstrated reduced surface free energy homogeneity distribution Under stress conditions cell test, Mechnomill-based treatment from untreated ETZ; however, Comil-based did not flowability. mechanical force exerted by Comil apparently insufficient interactions between However, tableted enhanced even when Comil.